Archive | Prostate Inflammation

Chronic pelvic pain in women

Chronic pelvic pain — Comprehensive overview covers symptoms, treatments of pelvic pain in women.

Article courtesy of All MayoClinic.com Topics

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Prostatitis and Your Diet

Prostatitis is an inflammation or infection of the prostate gland. It can cause abnormal urinary frequency and urgency, painful urination and ejaculation and if left untreated, chronic, recurrent symptoms. This common disorder affects approximately 10% of men. In addition to medication and nutritional supplements, certain diet additions can help alleviate the symptoms of and prevent prostatitis.

These nutrients and foods are beneficial for prostate health:

Vitamin C – Found in spinach, citrus fruits, red berries, kiwi, red and green bell peppers, tomatoes, strawberries, cabbage, and broccoli.

Zinc – Good sources include high protein foods such as red meat, fish and shellfish, dairy products, nuts, whole wheat foods, and legumes.

Saw Palmetto Berry – Can be steeped into a tea, or found in nutritional supplements.

Lycopene – Found in tomatoes.

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Urine Test Can Help Detect and Sort Prostate Cancer

Researchers report that an investigational urine test can detect and stratify prostate cancer in men with elevated prostate specific antigen (PSA).  According to Arul Chinnaiyan, MD, PhD, of the University of Michigan Medical School in Ann Arbor and colleagues, the test is based on the detection of a gene fusion that is specific to prostate cancer combined with another marker.  Stratifying patients by the combined marker identified groups with markedly different risks of cancer, high-grade cancer, and clinically significant cancer on biopsy.

This noninvasive test may allow some men with elevated PSA to avoid a needle biopsy.  Although many more men have elevated PSA than actually have cancer, the test could be an intermediate step before getting a biopsy.

The fusion that doctors look for in the test involves the genes transmembrane protease, serine 2 (TMPRSS2), and v-ets erythroblastosis virus E26 oncogene homolog (avian) (ERG).  This fusion appears in roughly half of all prostate cancers, but when it does appear, it is almost 100% specific for malignancy.  Through a series of experiments, the research team showed that the fusion gene was associated with indicators of clinically significant cancer at biopsy and prostatectomy.  The indicators included tumor size, high Gleason score at prostatectomy, and upgrading of Gleason grade at prostatectomy.

Because this fusion gene is not always present, the team created a model that combined it and the prostate cancer antigen 3 (PCA3) gene.

The researchers use the model to stratify 1,065 men who underwent biopsy into three groups – lowest, intermediate, and highest levels of the combined genes.

These tests, however, remain investigational.  Additionally, the researchers note that most of the men studied thus far have been Caucasian.  More studies are needed to see if the results can be generalized.

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Prostatitis: Can sexual activity make it worse?

Some men with prostatitis have pain with ejaculation or sexual intercourse.

Article courtesy of All MayoClinic.com Topics

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Alpha Blocker Improves Symptoms of Chronic Prostatitis

Recent findings show that treatment with a specific alpha blocker helps reduce symptoms and improve quality of life for men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).  This alpha-blocker, called silodosin, works by selectively relaxing the muscles in the neck of the urinary bladder and prostate.  It has been approved in Canada, the United States, the EU and Japan to treat symptoms of another prostate gland condition, benign prostatic hyperplasia, which is commonly referred to as an enlarged prostate.

Although CP/CPPS is the most common form of prostatitis, it is the most misunderstood and difficult to treat because the symptoms are very similar to other conditions and requires a significant amount of testing and screening to identify.

Curtis Nickel, a professor in the Department of Urology, practicing urologist at Kingston General Hospital and Canada Research Chair in Urologic Pain and Inflammation, emphasized that antibiotics are commonly used as a treatment, but they are not typically effective.  This could be because CP/CPPS does not seem to be caused by a bacterial infection.

CP/CPPS is a debilitating condition; patients with this condition suffer from discomfort in the lower pelvic area including the bladder area, testicles, and penis.  Symptoms may be severe and can include painful and frequent urination and difficult or painful ejaculation.  The cause of CP/CPPS is not known.

In Dr. Nickel’s study, about 60 percent of men reported feeling better after treatment with silodosin as opposed to 30 percent of participants who were given a placebo.  These results for patients feeling better is higher than a similar study he conducted several years ago that tested the effects of a different alpha blocker.

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Diabetes Mellitus is Associated With Increased Prostate Tumor Risk

Even though previous studies have suggested that men with diabetes mellitus (DM) have a lower risk of prostate cancer, Duke University researchers now report that their findings suggest that there is a relationship between DM and increased risk of aggressive prostate tumors.

Leah Gerber, MSc, and colleagues at the Duke University Prostate Center retrospectively analyzed statistical data from 1,848 men from the center’s database who underwent radical prostatectomy for prostate cancer at Duke University Medical Center between 1999 and 2009 and who had complete clinical information.  The number of patients with DM at time of surgery was 197 or 10.7% of men in the study.

After the researchers adjusted for demographic and clinical covariates, they found that men with preexisting DM had almost 50% increased risk of aggressive prostate cancer compared to men without DM.  Race and obesity did not appear to have an effect on this association.  These findings could partly explain why meta-analyses show that pre-existing DM is a significant risk factor for prostate cancer and overall mortality.  Gerber reports that if the findings hold in other populations, then the finding can be used to stratify patients by risk and identify therapeutic agents acting within the molecular pathways by both disease processes.  Additionally, the team reported that investigating pharmacological agents used to treat DM should continue to determine a potential benefit against prostate cancer.

The study data was presented at the 2011 annual meeting of the American Urological Association and funded by the Duke Division of Urologic Surgery.

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Mortality Rate for Prostate Cancer Higher in UK than US

According to researchers in the United Kingdom, prostate cancer is the cause of half of the deaths of men diagnosed with the disease, challenging the notion that prostate caner patients die with rather than of the disease.  Their data show that the number of deaths specifically from prostate cancer was around 20 percent.  In contrast, about 15 percent of men diagnosed with prostate cancer die from this disease in the United States.

Experts attribute this difference to the high uptake of testing for prostate-specific antigen (PSA) in asymptomatic men in the United States and the low uptake in the United Kingdom.

While British researchers say that routine PSA testing in the United States is picking up disease that might be clinically insignificant, thus leading to over-diagnosis and over-treatment of prostate cancer, American researchers argue that PSA testing detects prostate cancer at an earlier stage when it is still treatable and curable, leading to lower mortality rates in the United States.

The new data from the United Kingdom are from an analysis of 50,066 men diagnosed with prostate cancer between 1997 and 2006 from the Thames Cancer Registry.  Patients were followed until the end of 2007.  This registry covers a population of 12 million in Southeast England.  During the study period, 20,181 of the men died.  Prostate cancer was the cause of death in 49.7% of the men who had died.  These results held after researchers controlled for age, cancer stage, and first treatment.  Other causes of death included cardiovascular disease, other cancers, and pneumonia.

Prostate cancer was the cause of death in 74.3% of men who had stage IV cancer at diagnosis, in 46.4% of all men 75 years and older, and in 31% of all men who underwent radical prostatectomy.

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Acupuncture Relieves Prostate Cancer Treatment Side Effects

The main treatment for men with prostate cancer focuses significantly on reducing the level of testosterone in the body by either surgery or hormone therapy. Testosterone is needed by the cancer to grow and spread. Eliminating testosterone has been proven to keep the cancer in check. However, this type of therapy also causes side effects such as hot flashes, similar to those of women experiencing menopause. To relieve the hot flashes antidepressants are taken but these drugs have side effects of their own such as nausea, dry mouth, sleeplessness, altered appetite and sexual changes.

According to a study conducted by the Department of Radiation Oncology and the Acupuncture section of New York Methodist Hospital and Weill Cornell Medical College of Cornell University, both in New York, acupuncture provides long lasting relief to hot flashes, heart palpitations and anxiety due to side effects of the hormone given to counteract testosterone.

Researchers evaluated 14 men who were experiencing hot flashes due to hormone therapy for prostate cancer. Upon enrolling in the study, the men were given a hot flash score (HFS) to evaluate their discomfort from daily hot flashes. The mean initial HFS was 28.3.

Participants then received acupuncture 2 times a week for 30 minutes for 4 weeks. The mean HFS after 2 weeks of acupuncture dropped to more than half (10.3), at 6 weeks 7.5 and after 8 months 7.

Hani Ashamalia, M.D., lead author of the study and a radiation oncologist at New York Methodists Hospital said “Our study shows that physicians and patients have an additional treatment for something that affects many men undergoing prostate cancer treatment and actually has long term benefits, as opposed to side effects”

Currently, the researchers are designing a randomized clinical trial to further evaluate acupuncture after prostate cancer treatment and are encouraging men suffering from this symptom to talk to their doctors about enrolling.

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Research Study for Treatment of Lower Urinary Tract Symptoms (LUTS) Due To Benign Prostatic Hyperplasia (BPH)

Are you a man age 50 or older?

Do you have to urinate frequently during the day and at night?

Do you have trouble urinating?

Are these and other urinary problems interfering with your life and your relationships?

If you answered “yes” to the above questions, you may be a candidate for the L.I.F.T. Study.

The L.I.F.T. Study is an FDA approved research study to evaluate the UroLift system to support a premarketing application to FDA. Its purpose is to determine the safety and effectiveness of the UroLift system for the treatment of lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). The study is being conducted at urology practices throughout the U.S., in Canada and in Australia.

BPH is a non cancerous condition that causes the prostate to enlarge as men age. When the enlarged prostate presses on the urethra, it can cause bothersome urinary symptoms. The UroLift System is a minimally invasive approach to treating BPH that lifts/holds the enlarged prostate tissue out of the way so it no longer blocks the urethra. There is no cutting, heating or removal of prostate tissue. The goal of UroLift system treatment is to relieve symptoms so you can get back to your life and resume your daily activities.

The UroLift system is an investigational device as such is limited by Federal Law to investigational use only.

To find out more about L.I.F.T. Study and UroLift system treatment and study locations, go to www.neotract.com.

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Aspirin May Do More For Men Than Relieve Minor Aches and Pains

Aspirin has long been known to reduce inflammation and relieve minor aches and pains. But promising evidence has surfaced suggesting that aspirin can help drastically cut deaths among prostate cancer patients.

Dr. Kevin Choe of the University of Texas Southwestern Medical School in Dallas says men with prostate cancer who take anti-coagulants such as aspirin in addition to radiation therapy or surgery may be able to cut their risk of dying of cancer by more than half.

“Findings from this study—involving 5,275 men with localized prostate cancer—are promising, but, further studies are necessary before the addition of aspirin to prostate cancer therapy becomes standard treatment,” Choe, the study author, said.

Other studies have been conducted to test similar predictions, but many have had mixed results with anti-coagulants.

“If the cancer has already metastasized, then anti-coagulants may not be as beneficial,” explains Choe.
This study also found that aspirin led to the greatest benefits, when compared to other anti-coagulants.

In addition, aspirin had the most benefit for those patients with the most aggressive form of cancer.

“This is exciting news as patients with high-risk disease have the most aggressive cancer, with a high likelihood of dying from the disease, and the treatment options are currently limited,” Choe notes.

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